| 摘要 |
The disclosure relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims examples of such compounds are: (2S,4R)-4-(2-Chloro-benzenesulfonyl)-2-(1-cyano-cyclopropylcarbamoyl)-pyrrolidine-1-carboxylic acid 4-fluoro-phenyl ester; (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-cyclohexyl-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide; (2S,4R)-1-(2-Methoxy-ethyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide; (2S,4R)-1-[5-Methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide. The compound of formula (I) can be used as a medicament for the treatment of conditions such as diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease or diabetic nephropathy.
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