发明名称 |
DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF |
摘要 |
<p>Provides is a binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein VD is a first heavy chain variable domain; VD2 is a second heavy chain variable domain; C is a heavy chain constant domain; XI is a linker with the proviso that it is not CHI; X2 is an Fc region; n is 0 or 1; and wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein VD 1 is a first light chain variable domain; VD2 is a second light chain variable domain; C is a light chain constant domain; XI is a linker with the proviso that it is not CHI; X2 does not comprise an Fc region; nis 0 or 1; and wherein the binding protein binds TNF and IL-17A, wherein the heavy and light chain six CDRs have defined sequences. The antibodies can be used for various diseases, including immunological conditions and cancers.</p> |
申请公布号 |
NZ589434(A) |
申请公布日期 |
2012.11.30 |
申请号 |
NZ20090589434 |
申请日期 |
2009.06.03 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
GHAYUR, TARIQ;ISAKSON, PETER, C |
分类号 |
C07K16/20;C07K16/46;C12P21/08 |
主分类号 |
C07K16/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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