DEVICE AND METHODS FOR DETECTING ANALYTES IN SALIVA BY REMOVING MUCIN BEFORE ANALYSIS

摘要

A microfluidic device 1 for detecting the presence of one or more analytes in a saliva sample, comprises one or more pre-treatment regions 2, comprising a molecule for specifically or non-specifically removing at least a part of the fraction of mucin in the saliva sample interfering with detection of the one or more analytes, and a detection region 4 comprising a biosensor surface 5. The surface 5 comprises either molecules 6 capable of specifically binding the one or more analytes, or one or more analytes and/or molecules 6 which are structurally related to the analyte and bind analyte-specific probes.