Antigen-presenting scaffolds

摘要

Disclosed is an antigen-presenting scaffold having a rigid structure for presenting antigens to the immune system, wherein the compound has the formula: Scaffold-[L-(Antigen)t]y Wherein the scaffold comprises a group: Core-[Spacer]z Wherein the Core is selected from an aryl or heteroaryl group, an acetylenyl or vinyl group, a caged hydrocarbon group or a caged silicon containing group, and the Spacer is a group wherein each Spacer, alone or in combination with the Core, comprises at least one partially conjugated unbranched or branched moiety comprising at least two groups selected from aryl,heteroaryl, alkenyl, acetylenyl and carbonyl, and wherein L is a linking group or covalent bond, and the other substituents are as described within the specification. Also disclosed is the use of said compound in the manufacture of a medicament for treating or preventing a cancer, infectious disease, autoimmune disease or disease characterised by immunodeficiency.