发明名称 |
HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 |
摘要 |
Disclosed is a human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements. |
申请公布号 |
NZ593155(A) |
申请公布日期 |
2012.11.30 |
申请号 |
NZ20090593155 |
申请日期 |
2009.12.15 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
SLEEMAN, MARK W;MARTIN, JOEL H;HUANG, TAMMY T;MACDONALD, DOUGLAS |
分类号 |
C07K16/40;A61K39/395;A61P3/06;C12N9/64 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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