发明名称 |
URACIL COMPOUND HAVING INHIBITORY ACTIVITY ON HUMAN DEOXYURIDINE TRIPHOSPHATASE OR SALT THEREOF |
摘要 |
Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug. A uracil compound represented by the general formula (I) or a salt thereof:
wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents -SO 2 NR 1 R 2 or -NR 3 SO 2 -R 4 , wherein R 1 and R 2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R 3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R 4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like. |
申请公布号 |
HRP20120820(T1) |
申请公布日期 |
2012.11.30 |
申请号 |
HR2012P000820T |
申请日期 |
2012.10.11 |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
FUKUOKA, MASAYOSHI;YOKOGAWA, TATSUSHI;MIYAHARA, SEIJI;MIYAKOSHI, HITOSHI;YANO, WAKAKO;TAGUCHI, JUNKO;TAKAO, YAYOI |
分类号 |
C07D239/48;C07D401/06;C07D403/12;C07D405/12;C07D409/06;C07D409/12 |
主分类号 |
C07D239/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|