| 摘要 |
Disclosed is a compound of formula 6 or a physiologically acceptable salt thereof, wherein: each X1, X2, X3 and X4 is selected from N and CR7; one of X5, X6, X7 and X8 is N and the others are CH; X9 is selected from N and CH; Z is selected from phenyl, pyrazinyl, pyridinyl, pyridazinyl and piperazinyl; wherein each phenyl, pyrazinyl, pyridinyl, pyridazinyl or piperazinyl of Z is optionally substituted with an R6 group; R1, R2 and R3 are hydrogen; m is 1; R4 is selected from hydrogen, halo, difluoromethyl, trifluoromethyl and methyl; R6 is selected from hydrogen, halo and -C(O)R10; wherein R10 is methyl; and R7 is selected from hydrogen, halo, cyano, methyl and trifluoromethyl. The compound is useful for treating cancers associated with Wnt signalling activity such as colorectal cancer, breast cancer etc. |
