OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME

摘要

Disclosed is an ophthalmic device, comprising; a mass of material, the mass of material including a hydrophobic component, the hydrophobic component being present in an amount sufficient that the contact angle of the material is greater than 50 degrees, the hydrophobic component being formed of at least 80 per cent by weight hydrophobic acrylate; and therapeutic agent disposed upon a peripheral surface of the mass of material wherein the therapeutic agent is hydrophobic and has a partition coefficient Log P that is at least 1.0; wherein the mass of material is configured for insertion into an eye of a human and wherein attraction of the therapeutic agent to the hydrophobic acrylate provides for sustained release of the therapeutic agent such that less than 80 per cent by weight of the therapeutic agent is released from the mass of material over a period that is at least three days when the mass is submerged in basic salt solution.