发明名称 |
FKBP52-TAU INTERACTION AS A NOVEL THERAPEUTICAL TARGET FOR TREATING THE NEUROLOGICAL DISORDERS INVOLVING TAU DYSFUNCTION |
摘要 |
The invention relates generally to neuro-protection and repair in neurological disorders involving Tau dysfunction (including Alzheimer's disease). The invention describes AND INCLUDES a direct interaction between proteins FKBP52 and Tau. More particularly, the invention relates to a method for screening a drug for the prevention and treatment of neurological disorders involving Tau dysfunction comprising the following steps: a) determining the ability of a candidate compound, to modulate the interaction between a Tau polypeptide and a FKBP52 polypeptide and b) selecting positively the candidate compound that modulates said interaction. The present invention finally relates to diagnostic, prognostic, and monitoring assays of neurological disorders involving Tau dysfunction.
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申请公布号 |
US2012302595(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
US201013497907 |
申请日期 |
2010.09.24 |
申请人 |
BAULIEU ETIENNE;CHAMBRAUD BEATRICE;INSERM |
发明人 |
BAULIEU ETIENNE;CHAMBRAUD BEATRICE |
分类号 |
G01N33/566;A61K31/436;A61P25/00;C12Q1/68;G01N21/64;G01N33/573 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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