SYSTEMS AND METHODS FOR OPENING OF A TISSUE BARRIER IN PRIMATES

摘要

Method for cavitation-guided opening of a targeted region of tissue within a primate skull includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions. Systems for in vivo, cavitation-guided opening of a tissue in a primate are also provided.