| 发明名称 |
METHOD FOR IDENTIFICATION OF TUMOR RESPONSIVE TO TREATMENT USING ANTI-ErbB2 ANTIBODY |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a pharmaceutical for treatment of a tumor having a HER2 protein as a member of the ErbB receptor family of receptor tyrosine kinase. <P>SOLUTION: Administered is a fixed dosage of 420 mg every three weeks of recombinant monoclonal antibody 2C4 (rhuMAb2C4) containing VL domain of human 2C4 version 574, the amino acid sequence of VH domain, a human light chain, and heavy chain IgG1 (non-A allotype) constant region sequence. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2012232987(A) |
申请公布日期 |
2012.11.29 |
| 申请号 |
JP20120145330 |
申请日期 |
2012.06.28 |
| 申请人 |
GENENTECH INC;F HOFFMANN-LA ROCHE AG |
发明人 |
KOLL HANS;BOSSENMAIER BIRGIT;MUELLER HANS-JOACHIM;SLIWKOWSKI MARK X;KELSEY STEPHEN MICHAEL |
| 分类号 |
A61K39/395;C07K14/485;A61P35/00;A61P35/02;C07K16/28;C07K16/32;C07K16/46;G01N33/50;G01N33/53;G01N33/574 |
主分类号 |
A61K39/395 |
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