发明名称 |
BLOCKADE OF TL1A-DR3 INTERACTIONS TO AMELIORATE T CELL MEDIATED DISEASE PATHOLOGY AND ANTIBODIES THEREOF |
摘要 |
<p>Provided are methods and compositions for treating inflammatory or autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A. The interaction between DR3 and TL1A can be blocked by reducing expression of TL1A. The interaction between DR3 and TL1A can be blocked by administration of anti-DR3 antibodies. The interaction between DR3 and TL1A can be blocked by administration of anti-TL1A antibodies. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease (IBD).</p> |
申请公布号 |
WO2012161856(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
WO2012US28926 |
申请日期 |
2012.03.13 |
申请人 |
GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;SIEGEL, RICHARD M.;MEYLAN, FRANCOISE;SONG, YUN-JEONG |
发明人 |
SIEGEL, RICHARD M.;MEYLAN, FRANCOISE;SONG, YUN-JEONG |
分类号 |
A61K39/395;A61P11/06;A61P19/02;C12N15/62 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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