METHODS FOR REDUCING THE FORMATION OF TOBACCO SPECIFIC NITROSAMINES IN TOBACCO HOMOGENATES

摘要

In one aspect, there is provided a method for reducing the formation of 4-(methylnitrosamino)-1 - (3-pyridyl)-1 -butanone and N-nitrosonornicotine and N-nitrosoanatabine and N- nitrosoanabasine in a tobacco homogenate comprising the steps of: (a) providing a tobacco homogenate; (b) increasing the pH of the tobacco homogenate to at least about pH 6.0; (c) optionally measuring the concentration of 4-(methylnitrosamino)-1 -(3-pyridyl)-1 -butanone and N-nitrosonornicotine and N-nitrosoanatabine and N-nitrosoanabasine in the tobacco homogenate before and after the pH treatment in step (b); and (d) obtaining a tobacco homogenate in which the levels of 4-(methylnitrosamino)-1 -(3-pyridyl)-1 -butanone and N-nitrosonornicotine and N- nitrosoanatabine and N-nitrosoanabasine are reduced as compared to the levels of 4- (methylnitrosamino)-1 -(3-pyridyl)-1 -butanone and N-nitrosonornicotine and N-nitrosoanatabine and N-nitrosoanabasine in the tobacco homogenate provided in step (a).