NOVEL SPIROPIPERIDINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME

摘要

Provided is a novel compound which has an effect of promoting insulin secretion from pancreatic ß cells and is useful as a prophylactic and/or therapeutic agent for diseases associated with high blood sugar, such as diabetes. A compound represented by general formula (1), a salt thereof, or a solvate of the compound or the salt. (In the formula, ring A represents a C6-C10 aryl group or a five- to ten-membered heterocyclic group; Z represents O, N-R9, S(O)m, CH2 or C=O; each of R1, R2, R3 and R4 is independently absent or represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a hydroxyl group, a nitro group, a tetrazolyl group or the like; each of R5, R6 and R7 independently represents a hydrogen atom, a halogen atom, a cyano group or a carboxyl group; R8 represents a C1-6 alkyl group, a C6-10 aryl group or the like; each of R13 and R14 represents a hydrogen atom or a halogen atom; and R15 represents a hydrogen atom, a hydroxyl group or an oxo group.)