BONE TISSUE REGENERATING PEPTIDES

摘要

The present invention provides a recombinant or synthetic fusion polypeptide comprising a peptide component with bone tissue renerating activity, a linker peptide and an antimicrobial competence stimulating peptide with bone tissue renerating activity. The fusion polypeptide or antimicrobial competence stimulating peptide, which enhances osteogenic cell binding, is useful for repairing dental bony defects such as those caused by bone loss resulting from moderate to severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone derived or derived from bone-like hydroxyapatite or synthetic hydroxylapatite and/or a resorbable carrier such as high molecular weight polysaccharides. Furthermore, the fusion polypeptide or antimicrobial competence stimulating peptide alone of this invention is useful for treatment of fractures, as filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis, and also for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The fusion polypeptide or antimicrobial competence stimulating peptide can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.