PRIME-BOOST VACCINATION FOR VIRAL INFECTION

摘要

This disclosure relates to methods of inhibiting a viral infection, such as an HIV infection. The methods include administering a prime- boost vaccination to a subject, including a primer vaccine and a booster vaccine. The primer vaccine includes a DNA or adenoviral vector that expresses a viral antigen. The booster vaccine includes a lymphocytic choriomeningitis virus vector that expresses a mismatch of the viral antigen. In several embodiments, the viral antigen is an HIV antigen, such as HIV Env.