| 发明名称 |
USE OF EMT GENE SIGNATURES IN CANCER DRUG DISCOVERY, DIAGNOSTICS, AND TREATMENT |
| 摘要 |
The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase inhibitor, utilizing an EMT gene signature index score. The present invention further provides methods for treating patients with cancer that incorporate these methods. |
| 申请公布号 |
US2012302572(A1) |
申请公布日期 |
2012.11.29 |
| 申请号 |
US201213455972 |
申请日期 |
2012.04.25 |
| 申请人 |
KAN JULIE;THOMSON STUART;ARGAST GRETCHEN M.;O'CONNOR MATTHEW E.;ROBINSON MURRAY;FENG BIN;HEYER JOERG;CHIU MARIA I.;NICOLETTI RICHARD;AVEO PHARMACEUTICALS, INC.;OSI PHARMACEUTICALS, LLC |
发明人 |
KAN JULIE;THOMSON STUART;ARGAST GRETCHEN M.;O'CONNOR MATTHEW E.;ROBINSON MURRAY;FENG BIN;HEYER JOERG;CHIU MARIA I.;NICOLETTI RICHARD |
| 分类号 |
A61K31/517;A61K31/4985;A61P35/00;C40B30/04 |
主分类号 |
A61K31/517 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
