发明名称 |
METHODS FOR DEVELOPING ENDOTHELIAL CELLS FROM PLURIPOTENT CELLS AND ENDOTHELIAL CELLS DERIVED |
摘要 |
Disclosed herein is a method for developing human endothelial cells (ECs) from human embryonic stem cells (ESCs). The method is based on inhibition of TGF signaling following mesoderm induction and during vascular differentiation of hESC-derived cells. Also disclosed herein is a substantially pure and stable population of ECs that maintains a high degree of proliferation and phenotypic homogeneity for extended culture periods. Related pharmaceutical compositions and therapeutic methods are also disclosed. A reporter hESC line useful for tracking the development of ECs is also provided. |
申请公布号 |
US2012301443(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
US201013519473 |
申请日期 |
2010.12.23 |
申请人 |
RAFFI SHAHIN;JAMES DAYLON;CORNELL UNIVERSITY |
发明人 |
RAFFI SHAHIN;JAMES DAYLON |
分类号 |
C12N5/071;A61K35/12;A61P35/00;C12N5/10 |
主分类号 |
C12N5/071 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|