发明名称 |
METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING |
摘要 |
The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras. |
申请公布号 |
US2012301895(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
US201213568878 |
申请日期 |
2012.08.07 |
申请人 |
BAR-SAGI DAFNA;CHEN ZHAO;SKOWRONEK KARL;YADAV KAMLESH K.;THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;NEW YORK UNIVERSITY |
发明人 |
BAR-SAGI DAFNA;CHEN ZHAO;SKOWRONEK KARL;YADAV KAMLESH K. |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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