摘要 |
<p>Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25- hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample.</p> |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS, INC.;SAHAKIAN, NIVER, PANOSIAN;CAMPBELL, BRUCE, A.;LIN, SPENCER, HSIANG-HSI;FREEMAN, JAMES, VINCENT;LIAO, QIMU;EVANGELISTA, RAMON, A. |
发明人 |
SAHAKIAN, NIVER, PANOSIAN;CAMPBELL, BRUCE, A.;LIN, SPENCER, HSIANG-HSI;FREEMAN, JAMES, VINCENT;LIAO, QIMU;EVANGELISTA, RAMON, A. |