摘要 |
Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris. |
申请人 |
ALDER BIOPHARMACEUTICALS, INC.;MCNEILL, PATRICIA, DIANNE;JANSON, NICOLE;LESNICKI, GARY, L.;QI, PEI;LATHAM, JOHN, A.;GARCIA-MARTINEZ, LEON, F.;ALDERBIO HOLDINGS LLC |
发明人 |
MCNEILL, PATRICIA, DIANNE;JANSON, NICOLE;LESNICKI, GARY, L.;QI, PEI;LATHAM, JOHN, A.;GARCIA-MARTINEZ, LEON, F. |