发明名称 |
Dbait and its standalone uses thereof |
摘要 |
The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as a standalone anticancer drug in an efficient amount to be introduced in the tumor cell nuclei in order to trigger their death. |
申请公布号 |
AU2008204486(B2) |
申请公布日期 |
2012.11.29 |
申请号 |
AU20080204486 |
申请日期 |
2008.01.11 |
申请人 |
MUSEUM NATIONAL D'HISTOIRE NATURELLE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCH MEDICALE (INSERM);INSTITUT CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
DUTREIX, MARIE;SUN, JIAN-SHENG |
分类号 |
A61K38/00;A61P35/00;C12N15/115 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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