摘要 |
Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject. |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
CAI, YUPING, ANTHONY;GATELY, DENNIS PATRICK;HE, LUHONG;LEUNG, DONMIENNE, DOEN;LUAN, PENG;SWANSON, BARBARA ANNE;TANG, YING;WITCHER, DERRICK RYAN |