| 摘要 |
PURPOSE: An immunotherapeutic agent of a nanosome form containing retinoic acid is provided to ensure high retinoic acid transfer rate to a target site and to effectively suppress TNF-alpha and IL-17 generation. CONSTITUTION: An immunotherapeutic agent of a nanosome form contains a cell suspension and retinoic acid. The cell suspension is a cell membrane in eukaryotic cell lysate. The immune diseases are autoimmune diseases, inflammatory diseases, and cell, tissue, or organ transplantation rejection. A method for manufacturing the immunotherapeutic agent comprises: a step of suspending eukaryotic cells; a step of passing the suspension solution through a membrane filter; a step of adding retinoic acid to the solution; and a step of isolating immunotherapeutic agent of a nanosome from the solution. [Reference numerals] (AA) RA-containing nanosome
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