| 摘要 |
PURPOSE: A rivastigmine containing patch is provided to enhance stability and to express optimal emission pattern. CONSTITUTION: A rivastigmine containing patch comprises rivastigmine free base, a copolymer including butyl methacrylate and methylmethacrylate; and drug adhesive layer manufactured by using adhesive, and double layer of skin adhesive layer which includes silicon gluing agent. As adhesive of the drug adhesive layer, 58-66 parts by weight of 2- ethylhexylacrylat, 28-36 parts by weight of random copolymer and a random copolymer of 4-8 parts by weight of acrylic acid are used. The DURO-TAK™ 87-235A (henkel corp) is used as the adhesive of the drug adhesive layer. The copolymer of the methylmethacrylate and butyl methacrylate is the random copolymer of the methylmethacrylate and butyl methacrylate, and has the weight-average molecular weight of 130,000-170,000 g/mol.
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