发明名称 |
IMMUNOREGULATION BY ANTI-ILT5 ANTIBODIES AND ILT5-BINDING ANTIBODY FRAGMENTS |
摘要 |
<p>Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to induce an immunostimulatory effect in a T cell when such a T cell is contacted with an antigen presenting cell (APC) that has been previously contacted with the anti-ILT5 antibody or ILT5-binding fragment. Also disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to inhibit a response in a T cell (e.g., a pro-liferative response) when such a T cell is concomitantly contacted, or has previously been contacted, with an APC, which APC is simultaneously contacted with the anti-ILT5 antibody or ILT5-binding fragment. Also disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof for the treatment of various diseases and for use as immunostimulatory adjuvants.</p> |
申请公布号 |
EP2525822(A1) |
申请公布日期 |
2012.11.28 |
申请号 |
EP20110735200 |
申请日期 |
2011.01.20 |
申请人 |
TOLERX, INC. |
发明人 |
APOSTOLOU, IRINA;PONATH, PAUL;PONTE, JOSE;ROSENZWEIG, MICHAEL;VAICKUS, LOU |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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