发明名称 |
HUMAN MONOCLONAL ANTIBODIES AGAINST BACILLUSANTHRACIS PROTECTIVE ANTIGEN |
摘要 |
Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
申请公布号 |
EP1633785(B1) |
申请公布日期 |
2012.11.28 |
申请号 |
EP20040809410 |
申请日期 |
2004.05.21 |
申请人 |
MEDAREX, INC. |
发明人 |
KELER, TIBOR;BLANSET, DIANN;VITALE, LAURA, A.;LOWY, ISRAEL;SRINIVASAN, MOHAN |
分类号 |
C07K16/12;A61K;A61K39/395;A61K39/40;A61K47/48;A61K51/10;A61P31/04;C07H21/04;C07K16/00;C12N1/21;C12N15/13;C12N15/20;C12Q1/68;G01N33/53 |
主分类号 |
C07K16/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|