发明名称 Prodrugs of (3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-C]oxazol-7A-yl)methanol and derivatives thereof
摘要 A prodrug that has a prodrug moiety that degrades into a compound having the general Formula I with R3 being an alcoholic moiety can be useful in therapies for neurodegenerative diseases as well as cancer. Accordingly, the prodrug compounds can have a structure of Formula I, analogs thereof, derivatives thereof, or salts thereof, wherein: A and B are sulfur or oxygen; R1 and R2, in para, meta, or ortho position, are independently halogen, alkyl, alkoxy, haloalkyl, where R1 and R2 independently are straight chain, branched, substituted or unsubstituted; and R3 is a prodrug moiety. As examples, the prodrug can have a structure of any of Formulas I-V, which as shown in the specification.
申请公布号 US8318787(B2) 申请公布日期 2012.11.27
申请号 US20090538619 申请日期 2009.08.10
申请人 RAJEWSKI ROGER A.;TANOL MEHMET;GEORG INGRID GUNDA;MCINTOSH MICHELLE P.;UNIVERSITY OF KANSAS 发明人 RAJEWSKI ROGER A.;TANOL MEHMET;GEORG INGRID GUNDA;MCINTOSH MICHELLE P.
分类号 A61K31/424;C07D498/04 主分类号 A61K31/424
代理机构 代理人
主权项
地址
您可能感兴趣的专利