发明名称 |
Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts |
摘要 |
The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue. |
申请公布号 |
US8318137(B2) |
申请公布日期 |
2012.11.27 |
申请号 |
US20090609335 |
申请日期 |
2009.10.30 |
申请人 |
VAN ROMPAEY LUC JULIAAN CORINA;TOMME PETER HERWIG MARIA;BROWN ROBIN JOHN;GALAPAGOS N.V. |
发明人 |
VAN ROMPAEY LUC JULIAAN CORINA;TOMME PETER HERWIG MARIA;BROWN ROBIN JOHN |
分类号 |
A01K49/00;A61K48/00;C07K1/00;C12N15/11;G01N33/566 |
主分类号 |
A01K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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