摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to derivatives of non-steroid anti-inflammatory drugs (NSAID) of general formula: A-Y-X (Formula I), where A represents NSAID radical, selected from group, consisting of acetylsalicylic acid (ASA), diclofenac, naproxen, indomethacin, flurbiprofen, ibuprofen, ketoprofen and lumoracoxib, Y represents -C(O)O-, and X is selected from group, consisting of:and, which have improved anti-inflammatory properties, suitable for treatment of inflammation, pain and fever.EFFECT: obtained are NSAID derivatives with hydrosulfide (HS)-releasing fragment, for obtaining novel anti-inflammatory compounds, which have weakened side effects.23 cl, 16 dwg, 24 ex |