发明名称 |
INDENONCARBOXYLIC ACIDS DERIVATIVES AND THEIR USE FOR THE TREATMENT OF AND PREVENTING DIABETES AND DYSLIPIDAEMIA |
摘要 |
The present invention relates to a compound of formula I: (see formula I) wherein n is 1, 2 or 3; Y is o; N-OR9, wherein R9 is H or an aliphatic group; or CR10R11, wherein R10 and R11 is H or an aliphatic group; R1, R2, R3 and R4 are H or alkyl; R5 is Z; R6 is W; Z is optionally substituted alkyl, alkenyl, alkynyl, phenyl, or heteroaryl; W is -XL-CO2R7 or -X-L-Tet; Tet is tetrazolyl; L is an optionally substituted and/or interrupted aliphatic chain; X is O; NR8, wherein R8 is H; an aliphatic group; -CO-R' or -SO2-R', wherein R' is alkyl; or R8 is an optionally substituted aromatic carbocyclic group; or X represents S(O)m, wherein m is 0, 1 or 2; R7 is H or alkyl; or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, which can be used in the treatment of dyslipidaemia, atherosclerosis or diabetes.
|
申请公布号 |
CA2513310(C) |
申请公布日期 |
2012.11.27 |
申请号 |
CA20032513310 |
申请日期 |
2003.12.16 |
申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
ADJE, NATHALIE;BRUNET, MICHEL;ROCHE, DIDIER;ZEILLER, JEAN-JACQUES;YVON, STEPHANE;GUYARD-DANGREMONT, VALERIE;CONTARD, FRANCIS;GUERRIER, DANIEL;FERRAND, GERARD;BONHOMME, YVES |
分类号 |
C07C59/72;A61K31/19;A61P3/06;A61P3/10;A61P9/10;C07C45/46;C07C45/67;C07C45/68;C07C49/747;C07C49/755;C07C49/76;C07C51/00;C07C59/90;C07C65/21;C07C65/40;C07C67/30;C07C67/31;C07C69/712;C07C69/736;C07C69/76;C07C205/45;C07C211/60;C07C225/22;C07C227/00;C07C229/18;C07C233/33;C07C249/12;C07C251/44;C07C255/40;C07C309/65;C07C317/44;C07C319/14;C07C323/22;C07C323/52;C07C323/56 |
主分类号 |
C07C59/72 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|