发明名称 |
Use of leptin to treat metabolic abnormalities associated with lipoatrophy |
摘要 |
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment. |
申请公布号 |
US8318666(B2) |
申请公布日期 |
2012.11.27 |
申请号 |
US201113103294 |
申请日期 |
2011.05.09 |
申请人 |
DEPAOLI ALEXANDER M.;ORAL ELIF ARIOGLU;TAYLOR SIMEON I.;GARG ABHIMANYU;AMGEN, INC.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
DEPAOLI ALEXANDER M.;ORAL ELIF ARIOGLU;TAYLOR SIMEON I.;GARG ABHIMANYU |
分类号 |
A61K38/00;G01N33/53;A61K38/22;A61K38/55;A61K45/00;A61P3/04;A61P3/06;A61P3/10;A61P43/00;G01N33/74 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|