SiRNA-based cancer treatment

摘要

A double-strand oligonucleotide including two complementary oligonucleotide sequences forming a hybrid, each including at one of their 3′or 5′ends, one to five unpaired nucleotides forming single-strand ends extending beyond the hybrid, one of the oligonucleotide sequences being substantially complementary to a target sequence belonging to a DNA or RNA molecule to be specifically repressed, the target sequence belonging to a DNA or RNA molecule of a gene coding an angiogenic factor.