发明名称 |
GLP-1 PEGYLATED COMPOUNDS |
摘要 |
The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating conditions or disorders benefited by lowering blood glucose, decreasing food intake, decreasing gastric or intestinal emptying, increasing beta (~) cell population, or decreasing gastric or intestinal motility.
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申请公布号 |
CA2608311(C) |
申请公布日期 |
2012.11.27 |
申请号 |
CA20062608311 |
申请日期 |
2006.05.11 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
GLAESNER, WOLFGANG;MAYER, JOHN PHILIP;MILLICAN, ROHN LEE JUNIOR;VICK, ANDREW MARK;ZHANG, LIANSHAN |
分类号 |
A61K47/48;A61P3/10;C07K14/605 |
主分类号 |
A61K47/48 |
代理机构 |
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地址 |
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