发明名称 |
Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs |
摘要 |
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
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申请公布号 |
US8318756(B2) |
申请公布日期 |
2012.11.27 |
申请号 |
US20050294643 |
申请日期 |
2005.12.05 |
申请人 |
SPECTOR THOMAS;PETERS WILLIAM PAUL;KUFE DONALD W.;HUBER BRIAN;ADHEREX TECHNOLOGIES, INC. |
发明人 |
SPECTOR THOMAS;PETERS WILLIAM PAUL;KUFE DONALD W.;HUBER BRIAN |
分类号 |
A61K31/505 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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