发明名称 |
Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
摘要 |
The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1. |
申请公布号 |
US8318979(B2) |
申请公布日期 |
2012.11.27 |
申请号 |
US201113070703 |
申请日期 |
2011.03.24 |
申请人 |
COURVOISIER LAURENT;COURVOISIER, LEGAL REPRESENTATIVE VERONIQUE;DURET GERARD;GRAF STEPHANIE;PRAT-LACONDEMINE LAURENCE;REBIERE FRANCOIS;SABOURAULT NICOLAS;CEPHALON FRANCE |
发明人 |
COURVOISIER LAURENT;COURVOISIER, LEGAL REPRESENTATIVE VERONIQUE;DURET GERARD;GRAF STEPHANIE;PRAT-LACONDEMINE LAURENCE;REBIERE FRANCOIS;SABOURAULT NICOLAS |
分类号 |
C07C321/00;C07C315/02;C07C317/44 |
主分类号 |
C07C321/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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