| 摘要 |
FIELD: chemistry.SUBSTANCE: compound, represented by formula,or its pharmaceutically acceptable salt, where Yrepresents nitrogen atom or group, represented by CR, Yrepresents nitrogen atom or group, represented by CR, Yrepresents nitrogen atom or group, represented by CR, R, Rand R, which can be similar or different, each represents hydrogen atom, etc. (except in the case, when Yis CR, Yis CRand Yis CR), X represents oxygen atom, etc., Rrepresents C-Calkyl group, etc., Rrepresents optionally substituted phenyl group, etc., Rrepresents hydrogen atom, etc., and Rrepresents optionally substituted phenyl group, etc.), possesses inhibiting action with respect to S1P binding with its receptor Edg-1(SlP).EFFECT: obtaining composition, which can be used as therapeutic medication in case of autoimmune diseases, rheumatoid arthritis, asthma, atopic dermatitis, rejection after organ transplantation, cancer, retinopathy, psoriasis, osteoarthritis or age-related macula lutea degeneration, etc.13 cl, 9 ex, 1 tbl, 4 dwg |
