| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to condensed bicyclic compounds, having affinity with mineralocorticoid receptor (VR) of formula [I] and formula [ii], as well as to pharmaceutical compositions on their basis. In general formula[I[ and[ii] ring A represents benzene ring, which has substituent R, condensed with adjacent 6-membered heterocyclic ring, and said benzene ring additionally optionally is substituted with one or two substituent(s), selected from halogen atom and C-alkyl group, Rrepresents C-alkylsulfonyl amino group or C-alkyl aminosulfonyl group, Rand R(a) are similar or different and represent group, selected from hydrogen atom, C-alkyl group, and from 6- to 10-membered monocyclic or bicyclic aryl group (said aryl group is optionally substituted with halogen atom), (b) are combined with each other with formation of oxogroup or (c) are combined with each other on their ends together with adjacent carbon atom with formation of C-cycloalkyl group, X represents the following group =N-, =C(R)- or -CH(R)-, Rrepresents hydrogen atom, cyanogroup, halogen atom, C-alkyl group, C-alkenyl group, C-dicloalkyl group, C-alkanoyl group, carbamoyl group or Ccycloalkenyl group, Ar represents from 6- to 10-membered monocyclic or bicyclic aryl group, optionally containing one or several heteroatom(s), selected from sulphur atom, oxygen atom and nitrogen atom (said aryl group is optionally substituted with similar or different, one or two substituent(s), selected from halogen atom, cyanogroup, C-alkyl group, trihalogen- C-alkyl group and Calkoxygroup), and dotted line represents presence or absence of double bond, Xrepresents the following group =N- or =C(CN)-, Rrepresents hydrogen atom or halogen atom, Rand Rrepresent alkyl group, and Arrepresents phenyl group, optionally substituted with one or two group(s), which is(are) selected from halogen atom and trihalogenalkyl group.EFFECT: compounds can be applied as antihypertensive medication.15 cl, 18 tbl, 8 dwg, 71 ex |
