摘要 |
<p>PURPOSE: A precursor comprising is provided to simplify existing complex production steps for manufacturing radiopharmaceuticals to one single step, to reduce production cost because a large amount of phase change catalyst is not necessary, to facilitate separation of compounds after a reaction and to have quick reaction rate. CONSTITUTION: A precursor comprises an organic salt leaving group represented by chemical formula 1. In chemical formula 1, R1 is a C1-1000 hydrocarbon group which is 18F-labeled radioactive tracer except a part of -X-CH2-18F. Carbon of the backbone of the C1-100 hydrocarbon group can be substituted or unsubstituted by oxygen, nitrogen, sulfur, phosphorous or combinations thereof, halogen of the backbone can be substituted or unsubstituted by halogen, X is oxygen, sulfur or -C(O)-, and the leaving group is a substituted or unsubstituted C2-50 tetravalent ammonium salt. [Reference numerals] (AA) Leaving group</p> |