发明名称 |
PROCESS FOR PREPARATION OF TACROLIMUS |
摘要 |
Genetically modified strains of Streptomyces tsukubaensis (S. tsukubaensis) can be used for an improved fermentation process for the preparation of tacrolimus or a salt or derivative thereof by cultivation of these genetically modified strains. Novel genes allowing biosynthesis of allylmalonyl-CoA can be used for polyketide production with allylmalonyl extender unit. |
申请公布号 |
US2012295316(A1) |
申请公布日期 |
2012.11.22 |
申请号 |
US201013383182 |
申请日期 |
2010.07.09 |
申请人 |
PETKOVIC HRVOJE;KUSCER ENEJ;FUJS STEFAN;KOPITAR GREGOR;MRAK PETER;KOSEC GREGOR;LEK PHARMACEUTICALS D.D. |
发明人 |
PETKOVIC HRVOJE;KUSCER ENEJ;FUJS STEFAN;KOPITAR GREGOR;MRAK PETER;KOSEC GREGOR |
分类号 |
C12P17/16;C12N1/21;C12N15/52 |
主分类号 |
C12P17/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|