Heterocyclic compounds as CCR2b antagonists

摘要

Compounds of formula (I) 5 Q- L -W- C(=X) - Z - P wherein Q is an amine of the formula N(R')(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y' and Y2 which are linked 10 to groups L and C(X) respectively and Y' and Y2 are independently selected from N and C; X is 0, N, N-CN or S; Z is NR3 ; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, 15 are useful in the treatment of C-C chemokine mediated conditions.