The present invention is directed to N-linked quinoline amide compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
申请公布号
WO2012158474(A1)
申请公布日期
2012.11.22
申请号
WO2012US37409
申请日期
2012.05.11
申请人
MERCK SHARP & DOHME CORP.;KUDUK, SCOTT, D.;DIMARCO, CHRISTINA NG;YANG, ZHI-QIANG
发明人
KUDUK, SCOTT, D.;DIMARCO, CHRISTINA NG;YANG, ZHI-QIANG