| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an ecological and economical method for preparing enantiomerically pure 1-substituted-3-aminoalcohols represented by the formulae, particularly (S)-(-)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol. <P>SOLUTION: The method comprises asymmetrically hydrogenating a salt of an aminoketone and a corresponding carboxylic acid, particularly a salt of 3-N-methylamino-1-(2-thienyl)-1-propanone and a carboxylic acid in the presence of a catalyst containing a transition metal and a diphosphine ligand. <P>COPYRIGHT: (C)2013,JPO&INPIT |
