| 发明名称 |
BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS |
| 摘要 |
In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| 申请公布号 |
US2012295913(A1) |
申请公布日期 |
2012.11.22 |
| 申请号 |
US201113314117 |
申请日期 |
2011.12.07 |
| 申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;JONES CARRIE K.;STAUFFER SHAUN R.;BARTOLOME-NEBREDA JOSE MANUEL;MCDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;TONG HAN MIN |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;JONES CARRIE K.;STAUFFER SHAUN R.;BARTOLOME-NEBREDA JOSE MANUEL;MCDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;TONG HAN MIN |
| 分类号 |
A61K31/4985;A61P3/04;A61P3/10;A61P25/00;A61P25/06;A61P25/08;A61P25/14;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P35/00;C07D487/04 |
主分类号 |
A61K31/4985 |
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