SYSTEMS AND METHODS FOR OPTOGENETIC MODULATION OF CELLS WITHIN A PATIENT
摘要
<p>Cells within a patient are optogenetically modulated to treat various neurological disorders. In one example, a method includes delivering a viral vector including a genetic agent encoding for one or more light-sensitive proteins to a delivery site within a patient. The viral vector includes retrograde and/or anterograde transport properties such that the viral vector is configured to transduce the genetic agent into cells at the delivery site and into cells in a plurality of sites proximal and remote to the delivery site. A bioelectrical signal(s) related to a neurological condition of the patient is sensed, e.g. using an implanted electrode. Optical stimulation is delivered to cells transduced with the genetic agent by the viral vector to treat the neurological condition of the patient.</p>
申请公布号
WO2012134704(A9)
申请公布日期
2012.11.22
申请号
WO2012US27452
申请日期
2012.03.02
申请人
MEDTRONIC, INC.;POLETTO, CHRISTOPHER;GIFTAKIS, JONATHON, E.;KAEMMERER, WILLIAM, F.
发明人
POLETTO, CHRISTOPHER;GIFTAKIS, JONATHON, E.;KAEMMERER, WILLIAM, F.