发明名称 |
Integrin Alpha-2 Binding Agents and Use Thereof to Inhibit Cancer Cell Proliferation |
摘要 |
The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix; immunizing a mammal with the propagated cancer cells; and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.
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申请公布号 |
US2012294865(A1) |
申请公布日期 |
2012.11.22 |
申请号 |
US201213474872 |
申请日期 |
2012.05.18 |
申请人 |
WEISS STEPHEN J.;DUDLEY DAVID T.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
WEISS STEPHEN J.;DUDLEY DAVID T. |
分类号 |
A61K39/395;A61P9/00;A61P35/00;A61P43/00;C07K16/28;C12N1/19;C12N1/21;C12N5/09;C12N5/10;C12N15/13;C12N15/63;C12P21/02;C40B30/04;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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