METHOD FOR MAKING CUSTOMISED NANOPARTICLES, NANOPARTICLES AND USES THEREOF
摘要
The invention proposes a method for the production of biodegradable nanoparticles with an average particle size of less than 400 nm. According to the invention, in a first step a macromonomer is prepared in a ring opening polymerization process between a hydrophilic acrylate compound (A) as an initiator and hydrophobic cyclic monomers (B), wherein the macromonomer comprises at least two repetitive units based on the cyclic monomer. In a second step this macromonomer or a mixture of macromonomers and/or commercial biocompatible monomers is polymerized, e.g. in a starved, miniemulsion or emulsion radical polymerization in water in the presence of a surfactant to the nanoparticle without necessitating additional subsequent steps for the actual production of the nanoparticles. The invention furthermore pertains to correspondingly made nanoparticles and uses thereof.
申请公布号
WO2012156065(A1)
申请公布日期
2012.11.22
申请号
WO2012EP02054
申请日期
2012.05.14
申请人
ETH ZURICH;MOSCATELLI, DAVIDE;LATTUADA, MARCO;MORBIDELLI, MASSIMO;YU, YINGCHUAN