METHODS OF TREATING INFLAMMATORY CONDITIONS

摘要

The present invention provides methods of treating a &bgr;-arrestin2 mediated and/or GPR120 mediated response in a subject. The &bgr;-arrestin2 mediated and/or GPR120 mediated response can be inflammation, including diabetes, inflammation associated with obesity and obesity. The methods can comprise administering to a subject a therapeutically effective amount of a compound predicted to bind a &bgr;-arrestin2 molecule and/or GPR120, wherein the compound selectively activates a &bgr;-arrestin2-dependent signaling pathway of GPR120.