发明名称 |
SIGNATURE FOR THE DIAGNOSIS OF CANCER AGGRESSIVENESS AND GENETIC INSTABILITY |
摘要 |
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment. |
申请公布号 |
CA2835339(A1) |
申请公布日期 |
2012.11.22 |
申请号 |
CA20122835339 |
申请日期 |
2012.05.18 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
CAZAUX, CHRISTOPHE;HOFFMANN, JEAN-SEBASTIEN |
分类号 |
C12Q1/68;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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