发明名称 |
COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF TUMORS |
摘要 |
Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5kD and antibodies specific for OPN-5kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5kD. |
申请公布号 |
US2012294870(A1) |
申请公布日期 |
2012.11.22 |
申请号 |
US201213549633 |
申请日期 |
2012.07.16 |
申请人 |
TAKAFUJI VIVIAN;WANG XIN WEI;UNSWORTH EDWARD J.;GOLDSMITH PAUL K.;THE GOV. OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEP. OF HEALTH & HUMAN SERVICES |
发明人 |
TAKAFUJI VIVIAN;WANG XIN WEI;UNSWORTH EDWARD J.;GOLDSMITH PAUL K. |
分类号 |
C07K16/24;A61K39/395;A61P35/00;C12N1/19;C12N1/21;C12N5/09;C12N5/10;C12N5/18;C12N15/13;C12N15/63;C12Q1/68;C40B30/00;G01N21/76;G01N33/566;G01N33/577 |
主分类号 |
C07K16/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|